세미나 포스터 정광훈 교수.pdf

Revolutionizing bioimaging to elevate human health Kwanghun Chung, Ph.D. Massachusetts Institute of Technology 10:00, December 6, Wednesday, 2023 Online Seminar Abstract : Holistic imaging of diverse functional, anatomical, and molecular architecture that span multiple levels, from cells to an entire system, remains a major challenge in biology. In this talk, I will introduce a series of technologies that enable integrated multiscale imaging and molecular phenotyping of both animal tissues and human clinical samples. I will discuss how we engineer (1) the physicochemical properties of biological tissues, (2) molecular interactions, and (3) molecular transport all together to achieve integrated organ-wide 3D molecular analysis at unprecedented speed and resolution. I will also discuss how these technologies can be commercialized and deployed synergistically to study a broad range of biological questions. * Hosted by Jung Ho Hyun, Ph.D. Person in charge : BoGyu Jang/ Contact: jangbk87@dgist.ac.kr, 053)785-6101

2023-11-29

세미나 포스터 정광훈 교수.pdf

Revolutionizing bioimaging to elevate human health Kwanghun Chung, Ph.D. Massachusetts Institute of Technology 10:00, December 6, Wednesday, 2023 Online Seminar Abstract : Holistic imaging of diverse functional, anatomical, and molecular architecture that span multiple levels, from cells to an entire system, remains a major challenge in biology. In this talk, I will introduce a series of technologies that enable integrated multiscale imaging and molecular phenotyping of both animal tissues and human clinical samples. I will discuss how we engineer (1) the physicochemical properties of biological tissues, (2) molecular interactions, and (3) molecular transport all together to achieve integrated organ-wide 3D molecular analysis at unprecedented speed and resolution. I will also discuss how these technologies can be commercialized and deployed synergistically to study a broad range of biological questions. * Hosted by Jung Ho Hyun, Ph.D. Person in charge : BoGyu Jang/ Contact: jangbk87@dgist.ac.kr, 053)785-6101

2023-11-29

세미나 포스터 오요한 교수.pdf

Exploring Parkinson's disease pathology: novel insights through hPSC-based modeling and an optogenetically-induced alpha-synuclein aggregation system Yohan Oh, Ph.D. Department of Biomedical Science, Hanyang University 16:00, November 22, Wednesday, 2023 Venue : E7-236 Abstract : Recent advancements in differentiating human pluripotent stem cells (hPSCs) into specific types of neurons have paved the way for new methods to study human brain development and neurological diseases. In our study, we have utilized these hPSC-derived neuronal models to delve deeper into Parkinson's Disease (PD) research, focusing on the optogenetically-triggered accumulation of alpha- synuclein. We developed a system sensitive to light that quickly identifies substances that can prevent this accumulation, a crucial factor in PD. This system was further tested and verified using human midbrain dopaminergic neurons and organoids, proving its effectiveness. Our pioneering method highlights the significance of hPSC-based models in researching diseases and their potential in developing treatments, providing fresh perspectives on the molecular mechanisms of PD. * Hosted by Jinsoo Seo, Ph.D. Person in charge : BoGyu Jang/ Contact: jangbk87@dgist.ac.kr, 053)785-6101

2023-11-15

세미나 포스터 오요한 교수.pdf

Exploring Parkinson's disease pathology: novel insights through hPSC-based modeling and an optogenetically-induced alpha-synuclein aggregation system Yohan Oh, Ph.D. Department of Biomedical Science, Hanyang University 16:00, November 22, Wednesday, 2023 Venue : E7-236 Abstract : Recent advancements in differentiating human pluripotent stem cells (hPSCs) into specific types of neurons have paved the way for new methods to study human brain development and neurological diseases. In our study, we have utilized these hPSC-derived neuronal models to delve deeper into Parkinson's Disease (PD) research, focusing on the optogenetically-triggered accumulation of alpha- synuclein. We developed a system sensitive to light that quickly identifies substances that can prevent this accumulation, a crucial factor in PD. This system was further tested and verified using human midbrain dopaminergic neurons and organoids, proving its effectiveness. Our pioneering method highlights the significance of hPSC-based models in researching diseases and their potential in developing treatments, providing fresh perspectives on the molecular mechanisms of PD. * Hosted by Jinsoo Seo, Ph.D. Person in charge : BoGyu Jang/ Contact: jangbk87@dgist.ac.kr, 053)785-6101

2023-11-15