seminar_류훈교수.pdf

Epigenetic Mechanisms of Neurodegeneration Hoon Ryu Boston University Alzheimers Disease Center and Department of Neurology, Boston University School of Medicine 13:30-14:30, November 13:30-14:30, November Room 103, Building 1, DGIST Abstract : Huntingtons disease (HD) is an neurodegenerative disorder of mid- emotional distress, and progressive cognitive expansion of CAG repeats coding for Huntingtin (Htt) gene. In light of recent pathogenesis has evolved from mechanisms mechanisms of epigenetic modifications array of molecular modifications to regulation of non-coding RNAs pathophysiological features, alterationpathophysiological features, alteration remodeling of chromatin structure transcription are prominently linked ncRNAs and microRNAs are also associated In this review, we discuss how methylation modification of histone, and function of the HD pathogenesis. In addition, we histone deacetylase inhibitors and modifications and neuropathological sequels the epigenetic mechanisms of HD may biological markers and beneficial therapeutic Person in charge :So Jeong Jun / Contact: sojeong@dgist Epigenetic Mechanisms of Neurodegeneration in Brain Diseases Ryu, Ph.D. Boston University Alzheimers Disease Center and Department of Neurology, School of Medicine November 25, Monday, 2013November 25, Monday, 2013 Room 103, Building 1, DGIST an incurable and fatal hereditary -life onset characterized by chorea, cognitive decline. HD is caused by an for glutamine (Q) in exon 1 of the recent studies, understanding of HD mechanisms of genetic mutation of Htt to modifications. Epigenetic changes include an to both DNA and chromatin and a (ncRNAs). Indeed, among many alteration of histone code followed byalteration of histone code followed by and deregulation of neuronal gene to the pathogenesis of HD. Specific associated with neuronal damage in HD. methylation of DNA, post-translational of ncRNA are affected and involved in we summarize the therapeutic effects of and anti-caner drugs on epigenetic sequels in HD. Our understanding of may warrant future identification of novel therapeutic targets for HD. sojeong@dgist.ac.kr, 053)785-6103

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정광훈교수_세미나_포스터.pdf

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[dgist 보도자료] dgist 이상훈 교수팀, 로봇 의족 제어 신기술 개발! 하지 절단 환자의 삶의 질 향상 기대.hwp

2023.11.08.() . 053-785-1130, 010-4688-1130 053-785-1133, fax 053-785-1139 053-785-6224 DGIST , ! - (sEMG) - npj Flexible Electronics DGIST( ) (imperceptive) (Surface Electromyography Sensor) . . . . . , . , . , . DGIST (Microelectro Mechanical System) . . , () , . : , () : . () () . (, , ) , . , (plantar flexion) (dorsiflexion) . . DGIST , , (Bionic limbs) . , , , DGIST . npj Flexible Electronics(JCR IF 14.6, 2%) 10 25 . : 1. 1 2. DGIST 1. . [ 1] Imperceptive and Reusable Dermal Surface EMG for Lower Extremity Neuro-Prosthetic Control and Clinical Assessment Jaeu Park, Jinwoong Jeong, Minseok Kang, Nagwade Pritish, Youngjun Cho, Jeongdae Ha, Junwoo Yea, Kyung-In Jang, Hyojin Kim, Jumin Hwang, Byungchae Kim, Sungjoon Min, Hoijun Kim, Soonchul Kwon, Changsik Pak, Hyunsuk Suh, Joonpio Hong and Sanghoon Lee (npj Flexible Electronics (IF:14.6), 2023) , . . , . . . (PI) , . , . (, , ) . , , . . . . , . , . . . . , . , , . . . , , . . 1 2 . 2025 . / , . . . . . , (Bionic limbs) [ 1] . (MEMS) , . . [ 2] . (plantar flexion) (dorsiflexion) . [ 3] . , . . [ 4] , , (, , ) . , . [ 2] DGIST : ( / Lee, Sanghoon) : DGIST : 1983 : 053-785-6224 / hoonw@dgist.ac.kr 2017 6 () 2013 1 () 2009 2 () 2001 2023. 9 ~ DGIST 2018. 8 ~ 2023. 8 DGIST 2017. 7 ~ 2018. 7, (Singapore Institute for Neurotechnology, SINAPSE), / 27 (Advanced Materials, Advanced Science, Nano Energy, Biomaterials ) 6% 10 (5 6% 7) 15 (PI: 2, Co-PI: 3) Best Paper Award, Young scientist`s talk (2015, ) Best Student Award (2014, )

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[dgist 보도자료] dgist 이상훈 교수팀, 실시간 신경 자극을 조절할 수 있는 회전형 신경자극기 개발.hwp

2022.010.0025.() . 053-785-1130, 010-4688-1130 053-785-1133, fax 053-785-1139 053-785-6224 DGIST , - Nano Energy DGIST( ) (, , ) . , . , . DGIST , (multiple pulses) . : , (triboelectrification) (electrostatic induction) , . (pulse) : . (pulse width) . , (amplitude) . (pulse width) : 1/2 . . . , . . DGIST , , . . , , (Nano Energy) . : 1. 1 2. DGIST 1. . [ 1] Triboelectric neurostimulator for physiological modulation of leg muscle , , , , Pritish Nagwade, (, on-line published on 09.29, 2022) (Triboelctric nanogenerator, TENG) , triboelectric effect ( ) electrostatic induction ( ) . TENG . TENG . (RoTENS) . RoTENS (amplitude) . (rat) RoTENS . (twitching) (unfused tetanus), (fused tetanus) . RoTENS TENG . . , . RoTENS (Rotational Triboelectric Neurostimulator) . , . (rat) . . (pulse modulation) . , . . , . RoTENS . , . . TENG , . . TENG , RoTENS TENG . RoTENS , . [ 1] (a) RoTENS . (b) (c) [ 2] (a) (b) . (c) (d) . (e) 3 . (f) 3 . [ 3] (Common peroneal nerve) (Tibialis anterior muscle) EMG(electromyogram, ) [ 4] (Common peroneal nerve) (Tibialis anterior muscle) EMG(electromyogram, ) [ 5] (Common peroneal nerve) (Tibialis anterior muscle) EMG(electromyogram, ) (Tibial nerve) (Gastrocnemius muscle) EMG(electromyogram, ) [ 2] DGIST : ( / Lee, Sanghoon) : DGIST : 1983 : 053-785-6224 / hoonw@dgist.ac.kr 2017 6 () 2013 1 () 2009 2 () 2001 2018. 8 ~ , DGIST 2017. 7 ~ 2018. 7, (Singapore Institute for Neurotechnology, SINAPSE), ( 5) SCI 15 ( 5% 7, 10% 3) - Advanced Materials, Advanced Science, Nano Energy 10 IEEE MEMS, Transducers, IEEE Neural Engineering Best Paper Award, Young scientist`s talk (2015, ) Best Student Award (2014, )

2022-10-25