세미나 포스터 이승복 교수.pdf

Regulation of Presynaptic Plasticity by Actin and Its Regulators Seungbok Lee, PhD. School of Dentistry & Interdisciplinary Program in Neuroscience, Seoul National University 16:00, October 12, Wednesday, 2022 Abstract : Modulation of presynaptic actin dynamics is fundamental to synaptic growth and functional plasticity; yet the underlying molecular and cellular mechanisms remain largely unknown. To address this issue, we have used the glutamatergic neuromuscular junction (NMJ) of Drosophila as a model synapse. In the first part of my talk, I will present multiple lines of evidence that actin-regulatory Vav-Rac1-SCAR signaling independently regulates BMP- induced presynaptic growth and tetanic stimulation (TS)-induced presynaptic plasticity by driving BMP receptor macropinocytosis and synaptic vesicle (SV) mobilization, respectively. In the second part, I will present data demonstrating that Rap1, an upstream regulator of Vav activation, acts a convergent node of two signaling pathways mediating BMP-induced macropinocytosis and TS-induced RP mobilization. In the third part, I will present our initial characterization of other actin-regulatory proteins that are required for TS-induced presynaptic plasticity. * Host : Jinsoo Seo Person in charge : BoGyu Jang/ Contact: jangbk87@dgist.ac.kr, 053)785-6101

2022-10-05

세미나 포스터 이승복 교수.pdf

Regulation of Presynaptic Plasticity by Actin and Its Regulators Seungbok Lee, PhD. School of Dentistry & Interdisciplinary Program in Neuroscience, Seoul National University 16:00, October 12, Wednesday, 2022 Abstract : Modulation of presynaptic actin dynamics is fundamental to synaptic growth and functional plasticity; yet the underlying molecular and cellular mechanisms remain largely unknown. To address this issue, we have used the glutamatergic neuromuscular junction (NMJ) of Drosophila as a model synapse. In the first part of my talk, I will present multiple lines of evidence that actin-regulatory Vav-Rac1-SCAR signaling independently regulates BMP- induced presynaptic growth and tetanic stimulation (TS)-induced presynaptic plasticity by driving BMP receptor macropinocytosis and synaptic vesicle (SV) mobilization, respectively. In the second part, I will present data demonstrating that Rap1, an upstream regulator of Vav activation, acts a convergent node of two signaling pathways mediating BMP-induced macropinocytosis and TS-induced RP mobilization. In the third part, I will present our initial characterization of other actin-regulatory proteins that are required for TS-induced presynaptic plasticity. * Host : Jinsoo Seo Person in charge : BoGyu Jang/ Contact: jangbk87@dgist.ac.kr, 053)785-6101

2022-10-05