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Regenerative Medicine Technology Improving Stem Cell-based Therapy Developed

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  • 등록일. 2016.08.01
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Regenerative Medicine Technology Improving Stem Cell-based Therapy Developed

-DGIST research team creates extracellular matrix protein increasing regeneration efficacy of stem cells-

A DGIST research team developed a regenerative medicine technology which makes up for existing therapeutic shortcomings of stem cell treatment by using artificial protein.

Dr. Seong-Kyoon Choi and Dr. Won-Bae Chun from the Division of Nano and Convergence Research at DGIST and other researcher succeeded in developing a regenerative medicine technology which increases the regenerative efficacy of stem cell by making an artificial extracellular matrix protein.

The research team created for the first in the world thermo-sensitive recombinant protein replaceable with cellular matrix by activating integrin receptor. It is expected this original technology will bring out a breakthrough of existing stem cell treatment when treating artificial extracellular matrix protein in stem cell-based therapy.

Stem cells play a critical role in restoring wounded tissue or organ, gaining worldwide research attention. It is however pointed out that the treatment in the single use of stem cell procedure or product would significantly lower the survival and settling down rates of the cell. 

The research team said they developed the thermo-sensitive recombinant protein, an artificial extracellular matrix protein, based on the ideas that developing a biomaterial replaceable with wounded cellular matrix would maximize the efficacy of tissue regeneration and repair.

According to the research team, artificial extracellular matrix protein is being dissolved into a solution at below 20?? C, but would turn out to gel at the body temperature of 37?? C. When utilizing this nature of artificial extracellular matrix, it was confirmed that the survival rate of transplanted stem cell from the wounded tissue will improve by more than 30%. Compared with the single treatment of stem cell, it also has significant therapeutic efficacy


In addition, the histological examination and blood immune test done by the animal test also proved that artificial extracellular matrix protein does not cause any immune response and body infection.

It further confirmed that stem cell-based therapy using artificial extracellular matrix protein accelerates the function of beta-cell which takes part in cell multiplication and differentiation as well as insulin production. Accordingly, it is highly likely for this technology to be widely applied into stem cell technology development in the areas of nerve, cartilage, pancreas, and facial transplantation.

Dr. Choi at Nano and Energy Research Division said, “The research holds its significance in increasing the survival rate of transplanted stem cell and its rate of settling down. Our research will be further focused on developing therapeutic treatment using stem cell while therapeutic efficacy and safety fully ensured.

The research result has been published at the online edition of July 11 of the Journal of Controlled Release.