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DGIST identifies the cause of rheumatoid arthritis

  • 조회. 1008
  • 등록일. 2014.03.31
  • 작성자. Administrator

DGIST identifies the cause of rheumatoid arthritis
-Prof. Daehee Hwang(Department of New Biology, DGIST Graduate School) and his team opened the door towards the possibility of full recovery from rheumatoid arthritis-


DGIST revealed on the 8th that Prof. Daehee Hwang and his team working in the area of New Biology together with Prof. Wan-Wook Kim’s research team from Seoul St. Mary’s Hospital identified the cause of rheumatoid arthritis.

 

Rheumatoid arthritis is a chronic inflammation disease which occurs in around 1% of the entire population, and it characteristically destroys bone and cartilage as synovial cells proliferate, similarly to tumors(cancer). The cause had not been identified at present, but through this research, the process of how bone and cartilage is destroyed in patients with rheumatoid arthritis was identified for the first time.

 

The research team analyzed synovial cell DNA obtained from patients with rheumatoid arthritis to find 13 DNA candidates which are responsible for aggression and destruction, proving that Periostin and Twist DNA play a decisive role.

 

Also, by identifying that aggression and destruction significantly decreased when periostin and twist DNA were removed from synovial cells, it was suggested that this could be a new target for treating rheumatoid arthritis.

 

Prof. Daehee Hwang stated that the “road to a full recovery from rheumatoid arthritis was opened by proving a mechanism that selectively represses the destructiveness of synovial cells,” also adding that the “new analysis method of system biology applied in this research can be utilized in the diagnosis and treatment of various diseases in the future, including diseases related to rheumatoid arthritis.”


This research was supported by the Leading Characterization Research Project of the Ministry of Health and Welfare, and the research results were published in the December issue of the US Proceedings of the National Academy of Sciences (PNAS), an international academic journal in the field of medicine and science.  (*For full article of the paper, please visithttp://www.pnas.org/content/111/1/550.full)