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Calcium Channel Activity Regulation Mechanism and Its Principle of Action Identified

  • 조회. 469
  • 등록일. 2016.08.01
  • 작성자. Administrator

Calcium Channel Activity Regulation Mechanism and Its Principle of Action Identified

- Professor Byung-Chang Suh’ team proves the role of β2e subunit -

Professor Byung-Chang Suh of the Department of Brain & Cognitive Sciences succeeded in identifying the mechanism of activity regulation of calcium channels and its principle of action.

Calcium ion existing within neuron and muscle activates a nerve cell. It is also a key element in secretion of neurotransmitter and contraction of muscle. So far, various researches of calcium channel activation mechanism delivering Ca2+ into the cell have been done by many Korean and foreign researchers. However, those researches are mainly for synapse signal delivery, high blood pressure, epilepsy, learning and memory, and regulation of enzyme activation. It has not been yet clearly proved of the principle of calcium channel activation mechanism and its principle.

In this research, Professor Suh’s team proved of the principle of action of calcium channel 2e(β2e) subunit in the molecular level. Calcium channel 2e(β2e) subunit plays an important role in regulating the opening and closing of calcium channel while composing of complexity of calcium channel.

Usually combined with cell membrane, calcium channel’s 2e(β2e) subunit increases the activation of calcium channel. However, when calcium is brought into cell, the subunit would chip off from the membrane while leading to deactivate the calcium channel with high speed. Accordingly, the research also confirmed that the subunit interrupts the excessive inflow of calcium. It finally proved that calcium channel protein by itself acting as a feedback can voluntarily regulate the activation of calcium channel.

In addition, it also proved that calcium does not combine with protein within another cell, but Ca2+ combines directly with membrane phosphatide. Accordingly, such combination results in regulating the activation of calcium channel, while hindering calcium channel’s 2e (β2e) subunit to combine with membrane.

It determined a new mechanism that calcium ion within a cell can directly regulate the activation of calcium channel. It further establishes the activation principle of calcium channel by confirming that voltage-dependent calcium channel can be regulated by neurotransmitter or chemical stimulation such as hormone.

The research result will help to further understand the activation mechanism of calcium channel and identify the calcium channel regulating materials. It will also further influence the research of the other membrane protein which activates similarly in the membrane, providing the breakthrough of therapeutic material development for the areas of chronic pain, high blood pressure regulation.

Professor Suh said, “The activity regulation mechanism of calcium channel is very important to understand the basic function of a neuron. This research holds its significance to identify the activation principle which has never been well known yet.” He added, “We will continue to strive to do translational research for treating degenerative brain disease, high blood pressure, and epilepsy.”

The research result has been published on the online edition of Science Signaling, a sister publication of Science on July 6 (Wed).