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Identification of protein of visceral adipose tissues linked to early pathogenesis of T2DM

  • 조회. 1286
  • 등록일. 2014.04.28
  • 작성자. Administrator



DGIST revealed on April 1st that Dr. Daehee Hwang(Department of New Biology, DGIST Graduate School) and his team identified the protein of visceral adipose tissues linked to early pathogenesis of type 2 diabetes mellitus together with research team of Dr. Sung Hee Choi(Seoul Narional University Bundang Hospital), Dr. Kyong Soo Park(Seoul National University College of Medicine), and Dr. Sang-Won Lee(Korea University). 






Adipose tissue is recognized as an organ playing important pathophysiological roles in metabolic abnormalities, such as obesity, cardiovascular disease, and type 2 diabetes mellitus(T2DM). For the early treatment of T2DM, it is important to identify the protein of visceral adipose tissue(VAT) which is directly related with T2DM.






Research team of Professor Hwang and other teams have analyzed difference of VAT proteins between normal subjects and early T2DM patients, and identified six VAT proteins which is directly related to T2DM.






The VAT proteins found this time can ▲control the size of adipose tissue, ▲help free fatty acid oxidation, ▲control insulin signaling, and these substances are expected to be used for diabetes test and treatment.   






Professor Hwang said, "The research result this time is meaningful as it can provide a basis for understanding the link of a protein profile of VAT to early pathogenesis of T2DM."






Meanwhile, the research result was published on March issue of Molecular & Cellular Proteomics, which is a renowned journal in the field of proteomics. You can find the full article of the paper at : http://www.mcponline.org/content/13/3/811.full?sid=82072cd1-13db-42b4-a4dc-cf08e5718163